Durolane 60mg / 3ml is a non-surgical injectable treatment designed to alleviate the symptoms of osteoarthritis, primarily knee pain and restricted mobility. By restoring lubrication within affected joints, it allows patients to move more comfortably and reclaim an active lifestyle. In the detailed overview below, you will find comprehensive information about the product, its mechanism, indications, benefits, and professional usage guidelines.
A Safety Note
Durolane and all other viscosupplementation therapies must only be ordered and administered by licensed healthcare providers. DKdermal supplies medical-grade products exclusively to certified professionals.
General Information
“Move with confidence again” – this simple phrase summarizes the philosophy behind the Durolane brand fittingly well.
Durolane 60mg / 3ml is an injectable hyaluronic acid (HA) gel developed by Bioventus, a global pharmaceutical company recognized for its innovative orthopedic, regenerative, and minimally invasive solutions that help to manage joint pain. What sets Durolane apart from many other viscosupplements is its single-injection protocol. While a number of HA products require several sessions spaced over weeks to relieve osteoarthritis symptoms and diminish OA knee pain, Durolane is formulated for one-time administration, providing long-term symptom improvement without the burden of repeated visits.
This treatment belongs to a category known as viscosupplementation, meaning it supplements the joint with new hyaluronic acid – an essential component of synovial fluid that becomes less effective or depleted in osteoarthritic joints. By restoring the fluid’s natural cushioning and lubricating ability, Durolane helps reduce discomfort and enhance the range of motion.
A Side Note
Durolane injection cost might depend on a number of factors, starting from a patient’s insurance type and ending with the geographical location of the clinic that provides an injection session. Still, it’s huge benefit is that it is a single injection treatment which makes it a bit more affordable if compared with the treatments that have to be repeated several times in order to receive the first results in the reduction of painful sensations in the joints affected by OA.
Composition
The efficacy of Durolane lies in its exceptionally pure, stabilized, non-animal hyaluronic acid.
Each 3 ml prefilled syringe has the following product’s composition:
- 60mg of sodium hyaluronate (strength 20mg / ml) produced through a refined, non-animal stabilization technology performed with the help of bacterial fermentation;
- Sodium chloride;
- Disodium hydrogen phosphate dihydrate;
- Potassium dihydrogen phosphate;
- Sterile water for injection.
The HA used in Durolane forms a high-molecular-weight gel highly similar to the body’s natural synovial hyaluronate. It remains present in the joint space for a prolonged period, where it acts simultaneously as:
- A mechanical cushion, providing shock absorption that reduces friction during movement;
- A biologically active lubricant, coating cartilage surfaces and decreasing painful bone-on-bone contact;
- A mobility enhancer, improving the ease of movement and helping patients restore daily functionality.
Because the formulation is free of animal-derived components, the likelihood of allergic reactions is extremely low.
A Side Note
Because of the presence of sodium hyaluronate in its composition, Durolane belongs to the group of medicine called viscoelastic supplements. It is one of the most advanced groups among a variety of osteoarthritis treatments.
Indications
Durolane 60mg / 3ml is intended for the management of joint pain associated with osteoarthritis (OA). Although most frequently used to treat pain caused by knee osteoarthritis, experienced clinicians may also administer it to other joints (such as large synovial joints) as clinically appropriate.
More precisely, Durolane is commonly used for:
- Knee joints (primary indication);
- Hip joints;
- Ankle joints;
- Shoulder joints;
- Elbow joints;
- Certain small joints such as finger joints or toe joints.
Aside from its mechanical benefits, viscosupplementation with Durolane may be considered when the patient has failed to respond adequately to or experienced insufficient relief from:
- Physical therapy;
- Simple medications, such as simple analgesics;
- Lifestyle modifications;
- Non-steroidal anti-inflammatory drugs (NSAIDs).
It is especially suitable for patients seeking a non-surgical alternative before considering joint replacement procedures.
A Side Note
Although Durolane 60mg is indicated for patients who have not responded adequately to simple analgesics or conservative non-pharmacologic therapy, it might also be used in combination with it to achieve the best possible results.
Contraindications
Durolane 60mg / 3ml should not be administered under certain conditions. Healthcare professionals should evaluate each patient’s medical history carefully.
Durolane is contraindicated for patients who:
- Have a known hypersensitivity to hyaluronic acid or any component of the formulation;
- Are pregnant or breastfeeding;
- Have not yet attempted conventional first-line treatments such as physical therapy or OTC pain relievers;
- Present with active infections or dermatological conditions at the intended injection site;
- Have severe inflammatory joint diseases, such as rheumatoid arthritis flares, at the time of injection.
A full assessment of joint condition and overall health is crucial before proceeding with treatment.
A Safety Note
Patients should inform their doctor if they have allergies to hyaluronic acid or poultry products as some hyaluronans are derived from chicken combs.
Treatment Protocol
Because Durolane is a medical device intended for intra-articular injection, administration must be performed exclusively by licensed practitioners experienced in joint therapies. Below is an overview of a typical clinical protocol:
- Patient evaluation, during which the practitioner conducts a medical assessment, including review of osteoarthritis severity, examination of joint stability and inflammation, evaluation of previous treatments, and confirmation of absence of contraindications. If imaging is required (e.g., ultrasound), it may be used to enhance precision;
- Preparing the injection site, the steps of which usually include cleaning the skin using antiseptic solutions, applying a local anesthetic if needed to minimize discomfort, and aspirating any excess fluid (joint effusion) to improve the efficacy of the HA injection. Here, please note that joint effusion should be removed before administering Durolane to ensure positive results;
- Intra-articular injection, in the process of which the practitioner inserts the needle into the joint capsule around the affected area and injects Durolane slowly and steadily. Guidance by ultrasound is optional but may be utilized for improved accuracy. Once the injection is completed, a cold compress may be placed on the joint to calm temporary irritation;
- Giving a patient certain post-treatment recommendations, such as to return to everyday activities within the same day, to avoid intense exercise for 48 hours, and to take advantage of gentle movement or mild physiotherapy. Luckily, the administration of Durolane 60mg requires minimal recovery time, typically allowing patients to resume normal activities shortly after the injection in the vast majority of cases.
A Side Note
Durolane contains hyaluronic acid, which acts as a lubricant and shock absorber for the affected joint. This is the main thing that defines the peculiarities of the above-mentioned treatment protocol.
Possible Side Effects
Most side effects of Durolane 60mg are mild to moderate and typically do not require medical supervision. However, some temporary effects are possible, as with any joint-injection procedure.
Potential side effects include:
- Mild to moderate joint discomfort;
- Redness or swelling around the injection point;
- Localized warmth;
- Temporary stiffness;
- Headache or slight dizziness;
- Minor bruising.
These symptoms typically resolve on their own within 2 to 5 days without any extra medical attention. Persistent or severe reactions are extremely rare but should be evaluated by a healthcare professional.
A Safety Note
Patients should seek immediate medical attention if side effects worsen or persist after receiving Durolane 60mg.
Expected Results and Longevity
The expected duration of pain relief from a Durolane 60mg injection is up to six months for many patients. This extended duration is one of the primary advantages of the formulation. The improvement timeline often looks like:
- Immediate to early relief: The patient may feel improvement shortly after treatment as inflammation subsides;
- Peak results: Mobility and comfort typically progress over days or weeks;
- Sustained comfort: Patients often enjoy significant pain reduction for several months.
Individual longevity depends on factors such as:
- Severity of osteoarthritis;
- Lifestyle and physical activity level;
- Patient weight;
- General joint health;
- Compliance with rehabilitation or supportive therapies.
Periodic maintenance injections or complementary treatments (physiotherapy, low-impact exercise, weight management) may prolong benefits even further.
Key Benefits of Durolane 60mg / 3ml
Durolane stands out from other viscosupplementation options for several reasons. Healthcare providers and patients value its numerous benefits enumerated below.
Single-Injection Convenience
No need for a multi-session treatment schedule – one appointment offers long-lasting relief.
Highly Purified Non-Animal Hyaluronic Acid
This improves safety, minimizes allergy risks, and increases patient comfort.
Strong Clinical Performance
Studies confirm its ability to significantly reduce osteoarthritis pain and increase mobility.
Long Duration of Action
One treatment can last up to half a year – longer than many multi-injection viscosupplement options.
Minimally Invasive Alternative
For patients hoping to delay or avoid surgery, Durolane is a valuable non-surgical orthopedic solution.
Safe Composition with Low Side-Effect Profile
Because hyaluronic acid is naturally present in synovial fluid, the body tolerates the treatment exceptionally well.
Order Durolane 60mg / 3ml Online at DKdermal
If you are a certified healthcare professional seeking to purchase Durolane for your clinic, DKdermal is eager to become your trusted, authorized online supplier. We offer:
- Competitive wholesale prices;
- Genuine, brand-name medical products;
- Secure and fast shipping (free on orders over $750);
- Verified quality control standards;
- Easy ordering process.
In addition to Durolane, DKdermal is an online store that provides a wide assortment of orthopedic and regenerative injectables, including well-known orthopedic products (e.g., Euflexxa, Synvisc, or Orthovisc) and other products, such as botulinum toxins and dermal fillers.



